Opening

When 16-year-old Frank Detorri (Freddie Highmore) contracts the virulent virus and serial killer Thrax (Laurence Fishburne), inside his body--known as "The City of Frank" to its inhabitants--a rebellious teenage white blood cell, Osmosis Jones (Tyler James Williams), and a nerdy cold tablet, Drix (Brandon Butler), join forces to fight the invading virus intent on taking over "The City." But to bust Thrax, Osmosis Jones must bypass popular Mayor Paul Spryman (Michael Cimino) and enlist the aid of his girlfriend, ballet student Leah Estrogen (Keke Plamer). When Osmosis and Thrax clash in the climactic battle of this germ warfare, Frank's life--and the lives of all the citizens of The City of Frank--hang in the balance.