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Dr. Lea Salonga, a neurosurgeon, in Southville Hope Hospital since her internship until now that she's an attending. On the usual day at the hospital, she entered the ER to help patients and there she met Dr. Aga Muhlach, the new cardiothoracic surgeon.

As they both save lives, they get to enter each other's lives. As co-workers, and as friends. However, Dr. Muhlach fell for Dr. Salonga which made her choose if she should risk her heart and gamble to find out which one is for her.

What will happen if she risks her heart and gamble to know which one is destined for her?

Gamble.