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Annalise Karev is Alex Karev's younger genius sister. Even if she's way younger she graduated the same time he did, becoming a surgeon when he did. Now she's an attending for Trauma. When she gets a job offer to be the chief of trauma at another hospital in another town the twenty four year old takes the offer to finally break off on her own. She gets in contact with her uncle who offers her a room until she gets on her feet, but will her cousins depressive episodes pull her into a world she had no idea existed? Can she wrap her head around it enough to adapt?