The 12 Zodiac work for an organization dedicated to assassinate and kill whoever they are ordered to. Each specialize in their own technique each have their own way to kill. Think of this organization like a college, they live here. Orphaned at a young age they all found their way here and have dedicated themselves to a life a crime. They have courses to improve their skills and find themselves caught with romances and betrayal along the way. The life of an assassin is deadly and dangerous, one wrong move and they could get caught. They may be young but don't under estimate them...

Arabella Anderson is wanted. She's not exactly sure why, but she's on the run anyhow. Despite her attempts at staying hidden, she's discovered by the Justice League and asked to join they're covert missions team, Young Justice. Under the name Zenaida River, her and the team must infiltrate a gang of teenage drug dealers. Although, the Eximius Serum is no regular drug. It's unbelievably addictive, gives the user the powers of Superman and more, and can kill them instantly. Now, Ara and the team must to stop them from unleashing it into the world, without being discovered.